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Title   위암 조직에서 Midkine 유전자 발현 ( Midkine Gene Expression in Gastric Cancer Tissues )
Publicationinfo   1997 Jan; 029(02): 204-212.
Key_word   Gastric cancer, Midkine, Microvascular density
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Abstract   Purpose: We evaluated the clinical significance of the tumor growth factor, midkine (MK), in paired gastric cancer and normal tissues. Materials and Methods: Twenty paired normal and cancer tissues were tested for MK mRNA expression by Northern blot analysis. Vessel staining was done by immunohistochemical staining using CD-31 monoclonal antibody (Dako). Results: MK mRNA was mainly expressed in cancer tissues (11 versus 1). Lymph node metastasis, pathological stage and tumor differentiation did not correlate with MK expression. However, MK expression rate increased with increment in tumor size (p=0.05). Microvascular density did not correlate with tumor invasion, lymph node metastasis, and pathological stages. However, there was a tendency of vascular density increment with MK expression in Tl-T2 stage. Conclusion: MK was mainly expressed in larger gastric cancer tissues suggesting its role in cancer growth in vivo. But no definite correlation between MK expression and tumor microvascular density was found.
저 자   곽현주(Hyun Joo Gwak),김용배(Yong Bae Kim),민병소(Byung So Min),맹호영(Ho Young Maeng),송승훈(Seung Hoon Song),정혜원(Hye Won Jung),김태수(Tae Soo Kim),정희철(Hee Chul Chung),라선영(Seon Young Rah),정현철(Hyun Chul Chung),노성훈(Sung Hoon Roh),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),민진식(Jin